Gene information
Official symbol PLAT
Official full name plasminogen activator, tissue type
Gene type protein-coding gene
Chromosome8p11.21
Resources
Entrez Gene 5327
HGNC HGNC:9051
Ensembl ENSG00000104368
Vega OTTHUMG00000164072
UCSC uc003xos.3
GO terms: 94 records
GO Description Category LogP Number of genes Detail
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010755 regulation of plasminogen activation GO Biological Processes -10.5063145 8 More
GO:0010757 negative regulation of plasminogen activation GO Biological Processes -7.90707903 5 More
GO:0010955 negative regulation of protein processing GO Biological Processes -5.65848894 6 More
GO:0014074 response to purine-containing compound GO Biological Processes -9.77915279 26 More
GO:0014812 muscle cell migration GO Biological Processes -3.76678874 4 More
GO:0014909 smooth muscle cell migration GO Biological Processes -3.59511628 3 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0031045 dense core granule GO Cellular Components -4.70812216 5 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0031639 plasminogen activation GO Biological Processes -7.61185031 7 More
GO:0031960 response to corticosteroid GO Biological Processes -20.1789519 26 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0034698 response to gonadotropin GO Biological Processes -7.74299764 11 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042730 fibrinolysis GO Biological Processes -16.7830831 11 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0046683 response to organophosphorus GO Biological Processes -8.57801626 23 More
GO:0048167 regulation of synaptic plasticity GO Biological Processes -4.27696718 22 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051384 response to glucocorticoid GO Biological Processes -16.9609899 22 More
GO:0051591 response to cAMP GO Biological Processes -5.58721401 9 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070542 response to fatty acid GO Biological Processes -13.2686457 21 More
GO:0070613 regulation of protein processing GO Biological Processes -7.71267127 10 More
GO:0071371 cellular response to gonadotropin stimulus GO Biological Processes -6.11772924 8 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071383 cellular response to steroid hormone stimulus GO Biological Processes -3.35454241 16 More
GO:0071384 cellular response to corticosteroid stimulus GO Biological Processes -3.75773024 6 More
GO:0071385 cellular response to glucocorticoid stimulus GO Biological Processes -3.19400389 5 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071548 response to dexamethasone GO Biological Processes -4.38480829 9 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0097179 protease inhibitor complex GO Cellular Components -5.88286021 4 More
GO:0097180 serine protease inhibitor complex GO Cellular Components -4.49239295 3 More
GO:0098685 Schaffer collateral - CA1 synapse GO Cellular Components -5.81792293 14 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901654 response to ketone GO Biological Processes -10.4509771 32 More
GO:1901655 cellular response to ketone GO Biological Processes -4.22081481 14 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903317 regulation of protein maturation GO Biological Processes -7.52692728 10 More
GO:1903318 negative regulation of protein maturation GO Biological Processes -5.65848894 6 More
GO:1904090 peptidase inhibitor complex GO Cellular Components -5.67855223 6 More
GO:2000241 regulation of reproductive process GO Biological Processes -4.23306387 21 More
GO:2000242 negative regulation of reproductive process GO Biological Processes -4.69203828 7 More
GO:2000243 positive regulation of reproductive process GO Biological Processes -2.52693001 10 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 28 records
Molecular factor Omics type Application Objective MI type Reference
NM_000930.5:c.-7351C>T genomics myocardial infarction[diagnosis] myocardial infarction Ladenvall P et al. Thromb Haemost. 2002
PLAT 311bp ins/del genomics myocardial infarction[diagnosis] myocardial infarction van der Bom JG et al. Circulation. 1997
PLAT 311bp ins/del genomics acute myocardial infarction[diagnosis] acute myocardial infarction Abd El-Aziz TANA Rezk Cell Biochem Biophys. 2015
tissue-type plasminogen activator proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Sakamoto T et al. Am J Cardiol. 1992
tissue-type plasminogen activator proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Chen HZ et al. Chin Med J (Engl). 1990
tissue-type plasminogen activator proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Hamsten A et al. N Engl J Med. 1985
tissue-type plasminogen activator proteomics myocardial infarction[diagnosis] myocardial infarction Ridker PM et al. Lancet. 1993
tissue-type plasminogen activator proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Goto S et al. Cardiology. 1993
tissue-type plasminogen activator proteomics indocyanine green clearance[other] acute myocardial infarction van Griensven JM et al. Clin Pharmacol Ther. 1998
tissue-type plasminogen activator proteomics old myocardial infarction[diagnosis] old myocardial infarction Grzywacz A et al. Blood Coagul Fibrinolysis. 1998
tissue-type plasminogen activator proteomics silent myocardial ischemia[other] old myocardial infarction Grzywacz A et al. Blood Coagul Fibrinolysis. 1998
tissue-type plasminogen activator proteomics myocardial infarction[diagnosis] myocardial infarction Freeburn JC et al. Br J Haematol. 1998
tissue-type plasminogen activator proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Thogersen AM et al. Circulation. 1998
tissue-type plasminogen activator proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Jansson JH et al. Heart. 1998
tissue-type plasminogen activator proteomics myocardial infarction[diagnosis] myocardial infarction Ladenvall P et al. Thromb Haemost. 2002
tissue-type plasminogen activator proteomics myocardial infarction[diagnosis] myocardial infarction Salobir B et al. Angiology. 2002
tissue-type plasminogen activator proteomics death[prognosis (bad)] acute myocardial infarction Ganti AK et al. Pathophysiol Haemost Thromb. 2002
tissue-type plasminogen activator proteomics hypertension[prognosis (bad)] acute myocardial infarction Ganti AK et al. Pathophysiol Haemost Thromb. 2002
tissue-type plasminogen activator proteomics old myocardial infarction[diagnosis] old myocardial infarction Lundblad D et al. J Intern Med. 2005
tissue-type plasminogen activator proteomics good predictor death[prognosis (bad)] acute ST elevation myocardial infarction Lee CW et al. Atherosclerosis. 2008
tissue-type plasminogen activator proteomics glucose intolerance[prognosis (bad)] acute ST elevation myocardial infarction Knudsen EC et al. J Thromb Haemost. 2011
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics recurrent myocardial infarction[prognosis (bad)] myocardial infarction Wiman B et al. Arterioscler Thromb Vasc Biol. 2000
tissue-type plasminogen activator proteomics recurrent myocardial infarction;sudden cardiac death[prognosis (bad)] acute myocardial infarction Soeki T et al. Int J Cardiol. 2002
tissue-type plasminogen activator proteomics myocardial infarction[diagnosis] myocardial infarction Thogersen AM et al. Eur J Cardiovasc Prev Rehabil. 2004
tissue-type plasminogen activator proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Nilsson JB et al. J Thromb Thrombolysis. 2008
tissue-type plasminogen activator proteomics adverse events[prognosis (bad)] acute myocardial infarction Islam S et al. Int J Clin Exp Med. 2014
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics myocardial infarction[diagnosis] myocardial infarction Nordenhem A et al. Thromb Res. 2005
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics myocardial infarction[diagnosis] myocardial infarction Nordenhem A et al. Thromb Res. 2005
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